Lycorine Hydrochloride
Lycorine hydrochloride ndi yochokera ku ufa woyera mpaka kuyera kuchokera ku alkaloid lycorine, yomwe imapezeka mu zomera za Lycoris radiata (L'Her.), ndipo ndi ya banja la Amaryllidaceae. Lycorine hydrochloride ili ndi zotsatira zosiyanasiyana za mankhwala, kuphatikizapo anti-chotupa, anti-cancer, anti-HCV, anti-inflammatory, anti-bacterial, anti-virus, anti-angiogenesis, ndi anti-malaria properties. Imasungunuka m'madzi, DMSO, ndi ethanol. Kapangidwe kake ka mankhwala kamadziwika ndi zovuta za steroidal framework ndi kukoma kowawa komwe kumakhala ndi magulu angapo ogwira ntchito, kuphatikizapo magulu a hydroxyl ndi amino, omwe amathandizira pazochitika zake zamoyo.
| Dzina la malonda | Lycorine hydrochloride CAS: 2188-68-3 | ||
| Gwero la Zomera | Lycoris | ||
| Mkhalidwe wosungira | Sungani ndi chisindikizo kutentha kutentha | Tsiku la malipoti | 2024.08.24 |
| Kanthu | Standard | Zotsatira |
| Chiyero(Mtengo wa HPLC） | Lycorine hydrochloride≥98% | 99.7% |
| Maonekedwe | Ufa woyera | Zimagwirizana |
| Khalidwe lathupiizi | ||
| Kukula kwa tinthu | NLT100% 80Mesh | Zimagwirizana |
| Kutaya pakuyanika | ≤1.0% | 1.8% |
| Zolemera zitsulo | ||
| Zonse zitsulo | ≤10.0ppm | Zimagwirizana |
| Kutsogolera | ≤2.0ppm | Zimagwirizana |
| Mercury | ≤1.0ppm | Zimagwirizana |
| Cadmium | ≤0.5ppm | Zimagwirizana |
| Microorganism | ||
| Chiwerengero chonse cha mabakiteriya | ≤1000cfu/g | Zimagwirizana |
| Yisiti | ≤100cfu/g | Zimagwirizana |
| Escherichia coli | Osaphatikizidwa | Sizinazindikirike |
| Salmonella | Osaphatikizidwa | Sizinazindikirike |
| Staphylococcus | Osaphatikizidwa | Sizinazindikirike |
| Mapeto | Woyenerera | |
Mawonekedwe:
(1) Kuyera Kwambiri:Zogulitsa zathu zimakonzedwa mosamala kwambiri kuti zitsimikizire kuti ndizoyera kwambiri, zomwe ndizofunikira kwambiri kuti zikhale zogwira mtima komanso zotetezeka pazogwiritsa ntchito zosiyanasiyana.
(2) Katundu wa Anticancer:Zawonetsa zotsatira zazikulu za anticancer motsutsana ndi mitundu yosiyanasiyana ya khansa, onse mu vitro ndi mu vivo, kudzera munjira monga kukakamiza kumangidwa kwa cell, kuyambitsa apoptosis, ndi kuletsa angiogenesis.
(3) Zochita Zambiri:Lycorine hydrochloride imakhulupirira kuti imalumikizana ndi ma molekyulu angapo, ndikupatsa mphamvu zambiri motsutsana ndi ma cell a khansa.
(4) Kuchepa kwa Kawopsedwe:Imawonetsa kawopsedwe kakang'ono ku maselo abwinobwino, omwe ndi chinthu chofunikira kwambiri pakugwiritsa ntchito kwake ngati chithandizo chochizira.
(5) Mbiri ya Pharmacokinetic:Mankhwalawa adaphunziridwa chifukwa cha pharmacokinetics yake, kuwonetsa kuyamwa mwachangu komanso kuchotsedwa mwachangu ku plasma, yomwe ndiyofunikira pakuwongolera komanso kukonza chithandizo.
(6) Zotsatira za Synergistic:Lycorine hydrochloride yawonetsa zotsatira zowonjezereka zikagwiritsidwa ntchito limodzi ndi mankhwala ena, zomwe zingakhale zopindulitsa pogonjetsa kukana mankhwala ndi kukonza zotsatira za chithandizo.
(7) Zothandizidwa ndi Kafukufuku:Mankhwalawa amathandizidwa ndi kufufuza kwakukulu, kupereka maziko olimba ogwiritsidwa ntchito pa chitukuko cha mankhwala ndi ntchito zachipatala.
(8) Chitsimikizo cha Ubwino:Njira zowongolera zowongolera bwino zimakhazikitsidwa nthawi yonse yopangira kuti zitsimikizire kusasinthika komanso kudalirika kwazinthu.
(9) Ntchito Zosiyanasiyana:Ndiwoyenera kugwiritsidwa ntchito pofufuza ndi chitukuko pazamankhwala, kuphatikiza kupezeka kwa mankhwala ndi chitukuko cha chithandizo cha khansa.
(10) Kutsatira:Amapangidwa motsatira miyezo ya GMP kuti awonetsetse kuti zinthuzo zili zotetezeka komanso zogwira mtima.
(1) Makampani opanga mankhwala:Lycorine hydrochloride amagwiritsidwa ntchito popanga mankhwala oletsa ma virus komanso anticancer.
(2) Makampani a Biotechnology:Amagwiritsidwa ntchito pofufuza ndi kupanga mankhwala atsopano komanso kupanga mankhwala.
(3) Kafukufuku wazinthu zachilengedwe:Lycorine hydrochloride imaphunziridwa chifukwa cha ubwino wake wathanzi komanso mankhwala.
(4) Makampani a Chemical:Itha kugwiritsidwa ntchito ngati mankhwala apakatikati popanga zinthu zina.
(5) Makampani a zaulimi:Lycorine hydrochloride yafufuzidwa chifukwa cha kuthekera kwake ngati mankhwala ophera tizilombo komanso chowongolera kukula kwa mbewu.
Njira yochotsera lycorine hydrochloride nthawi zambiri imakhala ndi njira zotsatirazi kuti zitsimikizire kuyera kwa zosungunulira ndikuwongolera kuchira:
(1) Kusankhidwa kwa zinthu zopangira ndi kukonzanso:Sankhani zopangira zoyenera za Amaryllidaceae, monga mababu a Amaryllis, ndipo muzitsuka, ziume ndi kuziphwanya kuti zitsimikizire kuyera kwa zopangira ndikuyala maziko ochotsa.
(2)Kukonzekera koyambirira kwa ma enzyme:Gwiritsani ntchito ma enzyme ovuta (monga cellulase ndi pectinase) kuti muchepetse zopangira zophwanyidwa kuti ziwonde makoma a cell ndikuwongolera kutulutsa kotsatira.
(3)Kuchepetsa hydrochloric acid leaching:Sakanizani zopangira zopangira kale ndi dilute hydrochloric acid solution kuti mutenge lycorine. Kugwiritsa ntchito hydrochloric acid kumathandiza kuonjezera kusungunuka kwa lycorine, potero kumapangitsa kuti m'zigawo zikhale bwino.
(4)Akupanga mothandizidwa m'zigawo:Kugwiritsa ntchito akupanga-anathandiza m'zigawo luso akhoza imathandizira kuvunda ndondomeko ya lycorine mu zosungunulira ndi kusintha m'zigawo Mwachangu ndi chiyero.
(5)Kutulutsa kwa Chloroform:M'zigawo ikuchitika ndi zosungunulira organic monga chloroform, ndi lycorine anasamutsidwa ku gawo amadzimadzi kuti gawo organic kuyeretsa chandamale pawiri.
(6)Kubwezeretsa zosungunulira:Pambuyo pochotsa, zosungunulira zimabwezeretsedwanso kudzera mu evaporation kapena distillation kuti muchepetse kugwiritsa ntchito zosungunulira ndikuwongolera chuma.
(7)Kuyeretsa ndi kuyanika:Kupyolera mu njira zoyenera zoyeretsera ndi kuyanika, ufa wa lycorine hydrochloride umapezeka.
Panthawi yonse yochotsa, kuwongolera kusankha kwa zosungunulira, mikhalidwe yochotsa (monga pH mtengo, kutentha, ndi nthawi), ndi njira zoyeretsera zotsatizana ndi chinsinsi chotsimikizira chiyero cha zosungunulira ndikuwongolera kuchuluka kwa kuchira. Kugwiritsiridwa ntchito kwamakono m'zigawo ndi kuyeretsa zipangizo, monga akupanga extractors ndi mkulu-ntchito madzi chromatography (HPLC) machitidwe, kumathandizanso kusintha m'zigawo Mwachangu ndi mankhwala khalidwe.
Kusungirako: Sungani pamalo ozizira, owuma, ndi aukhondo, Tetezani ku chinyezi ndi kuwala kwachindunji.
Phukusi lalikulu: 25kg / ng'oma.
Nthawi Yotsogolera: Masiku 7 mutayitanitsa.
Alumali Moyo: 2 years.
Zindikirani: Zosintha mwamakonda zitha kukwaniritsidwa.
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Lycorine ndi alkaloid yopezeka mwachilengedwe yomwe imapezeka muzomera zingapo, makamaka m'banja la Amaryllidaceae. Nazi zina mwazomera zomwe zimadziwika kuti zili ndi lycorine:
Lycoris radiata(yomwe imadziwikanso kuti red spider lily kapena manjushage) ndi zitsamba zaku China zomwe zimakhala ndi lycorine.
Leucojum aestivum(chipale chofewa chachilimwe), amadziwikanso kuti ali ndi lycorine.
Ungernia sewertzowiindi chomera china cha banja la Amaryllidaceae chomwe chanenedwa kuti chili ndi lycorine.
Hippeastrum hybrid (kakombo wa Isitala)ndi zomera zina za Amaryllidaceae zomwe zimadziwika kuti lycorine.
Zomerazi zimagawidwa kwambiri m'madera otentha komanso otentha padziko lonse lapansi ndipo zakhala zikugwiritsidwa ntchito kwanthawi yayitali pamankhwala azikhalidwe. Kukhalapo kwa lycorine muzomera izi kwakhala nkhani yofufuza chifukwa cha kuthekera kwake kwamankhwala, kuphatikiza zotsatira zake zazikulu zolimbana ndi khansa monga zikuwonetsedwa m'maphunziro osiyanasiyana.
Lycorine ndi alkaloid yachilengedwe yokhala ndi zotsatira zambiri zama pharmacological, kuphatikiza kugwiritsa ntchito kwake pochiza khansa. Ngakhale zawonetsa zotsatira zabwino m'maphunziro osiyanasiyana, pali zina zomwe zanenedwapo komanso zolingalira zokhudzana ndi kugwiritsidwa ntchito kwake:
Kawopsedwe Wochepa: Lycorine ndi mchere wake wa hydrochloride nthawi zambiri amawonetsa kawopsedwe wochepa, womwe ndi khalidwe labwino pazachipatala. Zawonetsedwa kuti zili ndi zotsatirapo zoyipa pama cell abwinobwino amunthu komanso mbewa zathanzi, zomwe zikuwonetsa kusankhika kwa ma cell a khansa pamtundu wamba.
Zotsatira Zosakhalitsa za Emetic: Mseru ndi kusanza kwakanthawi zimawonedwa potsatira jakisoni wa lycorine hydrochloride wodutsa m'mitsempha kapena mtsempha, nthawi zambiri amatha mkati mwa maola 2.5 osakhudza chitetezo chamthupi kapena hematological.
Palibe Kugwirizana kwa Magalimoto Osokonezeka: Kafukufuku wasonyeza kuti mlingo wambiri wa lycorine sukhudza kugwirizanitsa magalimoto mu mbewa, monga momwe kuyesedwa ndi kuyesa kwa rotarod, kusonyeza kuti sikumayambitsa zotsatira zapakati pa mitsempha (CNS) zokhudzana ndi kuyendetsa galimoto.
Zomwe Zimagwira Ntchito Mwadzidzidzi: Pa mlingo wa 30 mg / kg, lycorine yakhala ikuwoneka kuti iwononge ntchito yoyendetsa galimoto mu mbewa, monga momwe zimasonyezedwera ndi kuchepa kwa khalidwe lakulera komanso kuwonjezeka kwa kusasunthika.
Makhalidwe Azambiri ndi Umoyo Wabwino: Mlingo wa 10 mg/kg wa lycorine sunasokoneze makhalidwe onse ndi ubwino wa mbewa, kutanthauza kuti uwu ukhoza kukhala mlingo woyenera kwambiri pakuwunika kwachirengedwe chamtsogolo.
Palibe Zotsatira Zazikulu Pakulemera kwa Thupi Kapena Umoyo Wathanzi: Kulamulira kwa lycorine ndi lycorine hydrochloride sikunabweretse zotsatira zowonekera pa kulemera kwa thupi kapena thanzi lonse pazithunzi za mbewa zokhala ndi chotupa.
Ndikofunikira kudziwa kuti ngakhale lycorine yawonetsa kuthekera pakufufuza koyambirira, kuyezetsa kwapoizoni kwanthawi yayitali kulibe. Kufufuza kwina kumafunika kuti mumvetsetse bwino zachitetezo chake, makamaka pakugwiritsa ntchito nthawi yayitali komanso m'malo azachipatala. Zotsatira zake ndi chitetezo cha lycorine chikhoza kusiyana malinga ndi mlingo, njira yoyendetsera, ndi makhalidwe a wodwala aliyense. Nthawi zonse funsani katswiri wa zachipatala musanaganizire kugwiritsa ntchito mankhwala atsopano kapena mankhwala.
