Lycorine Hydrochloride
Lycorine hydrochloride ndi ufa woyera mpaka woyera wochokera ku alkaloid lycorine, yomwe imapezeka m'zomera za Lycoris radiata (L'Her.), ndipo ndi ya banja la Amaryllidaceae. Lycorine hydrochloride ili ndi zotsatira zosiyanasiyana zamankhwala, kuphatikizapo chotupa, khansa, HCV, kutupa, mabakiteriya, mavairasi, angiogenesis, ndi malungo. Imasungunuka m'madzi, DMSO, ndi ethanol. Kapangidwe kake ka mankhwala kamadziwika ndi kapangidwe ka steroidal kovuta komanso kukoma kowawa ndi magulu angapo ogwira ntchito, kuphatikiza magulu a hydroxyl ndi amino, zomwe zimathandiza pa ntchito zake zamoyo.
| Dzina la chinthu | Lycorine hydrochloride CAS: 2188-68-3 | ||
| Gwero la Chomera | Lycoris | ||
| Mkhalidwe wosungira | Sungani ndi chisindikizo kutentha kwa chipinda | Tsiku la lipoti | 2024.08.24 |
| Chinthu | Muyezo | Zotsatira |
| Chiyero()HPLC） | Lycorine hydrochloride≥98% | 99.7% |
| Maonekedwe | Ufa woyera | Kutsatira |
| Munthu wodziwika bwinoics | ||
| Kukula kwa tinthu tating'onoting'ono | NLT100% 80Unyolo | Kutsatira |
| Kutayika pakuuma | ≤1.0% | 1.8% |
| Zolemera chitsulo | ||
| Zitsulo zonse | ≤10.0ppm | Kutsatira |
| Mtsogoleri | ≤2.0ppm | Kutsatira |
| Mercury | ≤1.0ppm | Kutsatira |
| Kadimumu | ≤0.5ppm | Kutsatira |
| Tizilombo toyambitsa matenda | ||
| Chiwerengero chonse cha mabakiteriya | ≤1000cfu/g | Kutsatira |
| Yisiti | ≤100cfu/g | Kutsatira |
| Escherichia coli | Sizinaphatikizidwe | Sizinapezeke |
| Salmonella | Sizinaphatikizidwe | Sizinapezeke |
| Staphylococcus | Sizinaphatikizidwe | Sizinapezeke |
| Mapeto | Woyenerera | |
Mawonekedwe:
(1) Kuyera Kwambiri:Katundu wathu amakonzedwa mosamala kuti atsimikizire kuti ndi woyera kwambiri, zomwe ndizofunikira kwambiri kuti agwire bwino ntchito komanso kuti akhale otetezeka pa ntchito zosiyanasiyana.
(2) Kapangidwe kake koletsa khansa:Yawonetsa zotsatira zazikulu zotsutsana ndi khansa motsutsana ndi mitundu yosiyanasiyana ya khansa, yonse mu vitro ndi mu vivo, kudzera mu njira monga kuyambitsa kuletsa kwa maselo, kuyambitsa apoptosis, ndikuletsa angiogenesis.
(3) Ntchito Yoganizira Zambiri:Amakhulupirira kuti Lycorine hydrochloride imagwirizana ndi zinthu zambiri zomwe zimapangitsa kuti maselo a khansa agwire ntchito bwino, zomwe zimathandiza kwambiri polimbana ndi maselo a khansa.
(4) Kuchepa kwa poizoni:Imakhala ndi poizoni wochepa ku maselo abwinobwino, zomwe ndizofunikira kwambiri pakugwiritsa ntchito kwake ngati mankhwala.
(5) Mbiri ya Mankhwala:Mankhwalawa aphunziridwa chifukwa cha pharmacokinetics yake, akuwonetsa kuyamwa mwachangu komanso kuchotsedwa mwachangu mu plasma, zomwe ndizofunikira kwambiri pakupereka mlingo ndi kukonzekera chithandizo.
(6) Zotsatira Zogwirizana:Lycorine hydrochloride yawonetsa zotsatira zabwino ikagwiritsidwa ntchito limodzi ndi mankhwala ena, zomwe zingakhale zothandiza polimbana ndi kukana mankhwala ndikuwonjezera zotsatira za chithandizo.
(7) Yothandizidwa ndi Kafukufuku:Chogulitsachi chikuthandizidwa ndi kafukufuku wambiri, zomwe zimapereka maziko olimba ogwiritsira ntchito popanga mankhwala ndi ntchito zachipatala.
(8) Chitsimikizo cha Ubwino:Njira zowongolera khalidwe la chinthucho zikugwira ntchito nthawi yonse yopanga kuti zitsimikizire kuti chinthucho chikugwirizana komanso kudalirika.
(9) Kugwiritsa Ntchito Mosiyanasiyana:Yoyenera kugwiritsidwa ntchito pofufuza ndi kupanga mankhwala, kuphatikizapo kupeza mankhwala ndi kupanga mankhwala a khansa.
(10) Kutsatira malamulo:Yopangidwa motsatira miyezo ya GMP kuti iwonetsetse kuti chinthucho chili chotetezeka komanso chogwira ntchito bwino.
(1) Makampani opanga mankhwala:Lycorine hydrochloride imagwiritsidwa ntchito popanga mankhwala oletsa mavairasi ndi khansa.
(2) Makampani a Biotechnology:Amagwiritsidwa ntchito pofufuza ndi kupanga mankhwala atsopano komanso mankhwala.
(3) Kafukufuku wa zinthu zachilengedwe:Lycorine hydrochloride imaphunziridwa chifukwa cha ubwino wake pa thanzi komanso mphamvu zake zamankhwala.
(4) Makampani opanga mankhwala:Itha kugwiritsidwa ntchito ngati mankhwala ophatikizana popanga mankhwala ena.
(5) Makampani a ulimi:Lycorine hydrochloride yafufuzidwa kuti ingathe kugwiritsidwa ntchito ngati mankhwala ophera tizilombo komanso oletsa kukula kwa zomera.
Njira yochotsera lycorine hydrochloride nthawi zambiri imaphatikizapo njira zofunika izi kuti zitsimikizire kuyera kwa chosungunulira ndikuwonjezera kuchuluka kwa kuchira:
(1) Kusankha ndi kukonza zinthu zopangira:Sankhani zinthu zoyenera zopangira zomera za Amaryllidaceae, monga mababu a Amaryllis, ndipo muzitsuke, ziume ndikuziphwanya kuti zitsimikizire kuti zinthu zopangirazo ndi zoyera ndikuyika maziko ochotsera pambuyo pake.
(2)Chithandizo choyambirira cha enzyme yophatikizana:Gwiritsani ntchito ma enzyme ovuta (monga cellulase ndi pectinase) kuti mukonzekere zinthu zopangira zophwanyika kuti ziwononge makoma a maselo a zomera ndikuwonjezera mphamvu yotulutsa zinthu pambuyo pake.
(3)Kuchepetsa kuchotsedwa kwa hydrochloric acid:Sakanizani zinthu zopangira zomwe zakonzedwa kale ndi yankho la hydrochloric acid lochepetsedwa kuti muchotse lycorine. Kugwiritsa ntchito hydrochloric acid kumathandiza kuwonjezera kusungunuka kwa lycorine, motero kumawonjezera mphamvu yotulutsa.
(4)Kuchotsa kothandizidwa ndi akupanga:Kugwiritsa ntchito ukadaulo wochotsa zinthu pogwiritsa ntchito ultrasound kungathandize kufulumizitsa njira yosungunula lycorine mu solvent ndikuwonjezera mphamvu ndi chiyero cha kuchotsa.
(5)Kuchotsa chloroform:Kuchotsa kumachitika ndi zinthu zosungunulira zachilengedwe monga chloroform, ndipo lycorine imasamutsidwa kuchoka pa gawo lamadzi kupita ku gawo lachilengedwe kuti ipitirize kuyeretsa chinthu chomwe chikufunidwa.
(6)Kubwezeretsa zosungunulira:Pambuyo pochotsa, chosungunuliracho chimabwezeretsedwanso kudzera mu nthunzi kapena kusungunuka kuti chichepetse kugwiritsa ntchito zosungunulira ndikukweza ndalama.
(7)Kuyeretsa ndi kuumitsa:Kudzera mu njira zoyenera zoyeretsera ndi kuumitsa, ufa woyera wa lycorine hydrochloride umapezeka.
Mu ndondomeko yonse yochotsera, kuwongolera kusankha zosungunulira, momwe zotulutsira (monga pH, kutentha, ndi nthawi), ndi njira zotsukira zotsatira ndiye chinsinsi chotsimikizira kuyera kwa zosungunulira ndikukweza liwiro lobwezeretsa. Kugwiritsa ntchito zida zamakono zochotsera ndi kuyeretsa, monga zotulutsira za ultrasonic ndi makina apamwamba amadzimadzi a chromatography (HPLC), kumathandizanso kukonza magwiridwe antchito ochotsera ndi mtundu wa zinthu.
Kusunga: Sungani pamalo ozizira, ouma, komanso oyera, Tetezani ku chinyezi ndi kuwala kolunjika.
Phukusi Lochuluka: 25kg/ng'oma.
Nthawi Yotsogolera: Masiku 7 mutatha kuyitanitsa.
Moyo wa Shelf: Zaka ziwiri.
Ndemanga: Ma specifications opangidwa mwamakonda amathanso kukwaniritsidwa.
Express
Zolemera zosakwana 100kg, masiku 3-5
Utumiki wosavuta kutenga katundu pakhomo ndi khomo
Panyanja
Kupitirira 300kg, Pafupifupi masiku 30
Pakufunika katswiri wopereka chilolezo kuchokera ku doko kupita ku doko
Ndi Ndege
100kg-1000kg, Masiku 5-7
Pakufunika katswiri wopereka chithandizo kuchokera ku eyapoti kupita ku eyapoti
Bioway Organic yalandira satifiketi ya USDA ndi EU organic, BRC, ISO, HALAL, KOSHER, ndi HACCP.
Lycorine ndi alkaloid yachilengedwe yomwe imapezeka m'zomera zingapo, makamaka mkati mwa banja la Amaryllidaceae. Nazi zina mwa zomera zomwe zimadziwika kuti zili ndi lycorine:
Lycoris radiata(yomwe imadziwikanso kuti kangaude wofiira kapena manjushage) ndi chomera chachikhalidwe cha ku China chomwe chili ndi lycorine.
Leucojum aestivum(chipale chofewa cha chilimwe), chimadziwikanso kuti chili ndi lycorine.
Ungernia sewertzowiindi chomera china chochokera m'banja la Amaryllidaceae chomwe chanenedwa kuti chili ndi lycorine.
Hippeastrum hybrid (kakombo wa Isitala)ndi zomera zina zokhudzana ndi Amaryllidaceae ndizodziwika bwino zomwe zimapanga lycorine.
Zomera izi zimapezeka kwambiri m'madera otentha komanso otentha padziko lonse lapansi ndipo zakhala zikugwiritsidwa ntchito kwa nthawi yayitali ngati mankhwala achikhalidwe. Kupezeka kwa lycorine m'zomera izi kwakhala nkhani yofufuzidwa chifukwa cha mphamvu zake zamankhwala, kuphatikizapo zotsatira zake zazikulu zotsutsana ndi khansa monga momwe zasonyezedwera m'maphunziro osiyanasiyana.
Lycorine ndi alkaloid yachilengedwe yokhala ndi zotsatira zosiyanasiyana zamankhwala, kuphatikizapo kugwiritsidwa ntchito kwake pochiza khansa. Ngakhale kuti yawonetsa zotsatira zabwino m'maphunziro osiyanasiyana, pali zotsatirapo zina zomwe zanenedwa komanso zoganizira zokhudzana ndi kugwiritsidwa ntchito kwake:
Kuchepa kwa Poizoni: Lycorine ndi mchere wake wa hydrochloride nthawi zambiri zimakhala ndi poizoni wochepa, zomwe ndi khalidwe labwino pa ntchito zachipatala. Zawonetsedwa kuti sizimakhudza kwambiri maselo abwinobwino a anthu ndi mbewa zathanzi, zomwe zikusonyeza kuti maselo a khansa amasankha bwino kuposa minofu yabwinobwino.
Zotsatira Zosakhalitsa za Kutuluka kwa Mphuno: Kusanza ndi kusanza kwa kanthawi kochepa kwawonedwa pambuyo pobayidwa ndi lycorine hydrochloride m'mitsempha kapena pansi pa khungu, nthawi zambiri kumachepa mkati mwa maola 2.5 popanda kusokoneza chitetezo cha michere ya m'thupi kapena magazi.
Palibe Kugwirizana kwa Magalimoto Owonongeka: Kafukufuku wasonyeza kuti kuchuluka kwa lycorine kosalekeza sikukhudza kugwirizana kwa kayendedwe ka magalimoto m'makoswe, monga momwe adayesera ndi mayeso a rotarod, zomwe zikusonyeza kuti sizimayambitsa zotsatira zoyipa za dongosolo la mitsempha (CNS) zokhudzana ndi kayendetsedwe ka magalimoto.
Zotsatira pa Ntchito Yodziyimira Payokha: Pa mlingo wa 30 mg/kg, lycorine yawonedwa kuti imalepheretsa ntchito yodziyimira payokha mwa mbewa, monga momwe zikuwonetsera kuchepa kwa kulera komanso kuwonjezeka kwa kusayenda.
Khalidwe Lonse ndi Ubwino: Mlingo wa 10 mg/kg wa lycorine sunasokoneze machitidwe onse ndi ubwino wa makoswe, zomwe zikusonyeza kuti uwu ukhoza kukhala mlingo wabwino kwambiri wowunikira mphamvu ya chithandizo chamtsogolo.
Palibe Zotsatirapo Zoipa Kwambiri pa Kulemera kwa Thupi kapena Mkhalidwe wa Thanzi: Kupereka lycorine ndi lycorine hydrochloride sikunabweretse zotsatirapo zoyipa pa kulemera kwa thupi kapena thanzi lonse mwa mbewa zokhala ndi chotupa.
Ndikofunikira kudziwa kuti ngakhale kuti lycorine yawonetsa kuthekera kochita kafukufuku wamankhwala asanachite opaleshoni, kuwunika kwa poizoni kwa nthawi yayitali sikukukwanirabe. Kafukufuku wowonjezereka akufunika kuti timvetsetse bwino momwe imakhalira yotetezeka, makamaka pakugwiritsa ntchito kwa nthawi yayitali komanso m'malo azachipatala. Zotsatirapo zake komanso chitetezo cha lycorine zimatha kusiyanasiyana kutengera mlingo, njira yoperekera, ndi mawonekedwe a wodwala aliyense. Nthawi zonse funsani katswiri wa zaumoyo musanaganizire kugwiritsa ntchito chowonjezera chilichonse chatsopano kapena chithandizo.
