Corydalis Extract Tetrahydropalmatine (dl-THP)
Tetrahydropalmatine (THP), yomwe imadziwikanso kuti dl-THP, Corydalin hydrochloride, kapena Corydalin Tube Extract, ndi mankhwala omwe amagawidwa m'gulu la isoquinoline alkaloid. Amatengedwa kuchokera ku tuber ya chomera cha ku China cha Corydalis yanhusuo. THP ndi chinthu chopanda mtundu kapena chachikasu chopepuka chomwe chili ndi kukoma kowawa pang'ono komanso kutentha kwa 147-149°C. Sichisungunuka m'madzi koma chimasungunuka kwambiri mu ether, chloroform, ndi ethanol. Mchere wake wa hydrochloride ndi sulfate umasungunuka m'madzi.
THP yaphunziridwa kuti ipeze zotsatira zosiyanasiyana za mankhwala, kuphatikizapo kuletsa ululu, kupweteka, kuteteza mitsempha, kuphatikizika kwa ma platelet, kuphatikizika kwa zilonda, kupha chotupa, ndi kuphatikizika kwa mankhwala osokoneza bongo. Amakhulupirira kuti imagwira ntchito yake yochepetsa ululu posintha ntchito ya central dopamine receptor ndipo yawonetsa kuthekera koteteza ma neuron ku kuvulala kwa ischemic. Kuphatikiza apo, THP yawonetsa zotsatira za kuphatikizika kwa ma platelet ndipo yafufuzidwa kuti ingathandize pochiza zilonda, kuletsa kukula kwa maselo a chotupa, komanso kuthandiza pakuledzera ndi mankhwala osokoneza bongo.
Ponseponse, Tetrahydropalmatine (dl-THP) ndi mankhwala okhala ndi zinthu zosiyanasiyana zamankhwala ndipo akhala akufufuzidwa kwambiri kuti adziwe momwe angagwiritsire ntchito pochiza. Kuti mudziwe zambiri funsani.grace@biowaycn.com.
Nazi zinthu zomwe Tetrahydropalmatine (THP) ili nazo komanso ubwino wake pa thanzi:
1. Kapangidwe ka mankhwala ochepetsa ululu:THP imawonetsa mphamvu zochepetsa ululu mwa kusintha ntchito ya central dopamine receptor, zomwe zimathandiza kuchepetsa ululu popanda kukhala ndi mphamvu yowonjezera.
2. Zotsatira Zoteteza Mitsempha:THP yawonetsa kuthekera koteteza ma neuron ku kuvulala kwa ischemic, kuchepetsa apoptosis ya neuron, komanso kuchepetsa kuchuluka kwa glutamate muubongo, zomwe zingathandize kuti ubongo ukhale ndi mphamvu zoteteza.
3. Kuchulukana kwa Magazi Oletsa Kutupa:THP yapezeka kuti imaletsa kusonkhana kwa ma platelet, zomwe zingachepetse chiopsezo cha magazi kuundana komanso zochitika zina zokhudzana ndi mtima.
4. Thandizo la Thanzi la M'mimba:THP yawonetsa mphamvu zotsutsana ndi zilonda zam'mimba ndipo ingathandize kuchepetsa kutulutsa asidi m'mimba, kupereka mpumulo ku zilonda zam'mimba ndi matenda ena ofanana nawo.
5. Kuthekera kwa Ntchito Yolimbana ndi Chotupa:THP yawonetsa mphamvu ya cytotoxic pa maselo a chotupa, zomwe zikusonyeza kuti ikhoza kukhala ndi gawo loletsa kukula kwa chotupa.
6. Makhalidwe Oletsa Kumwa Mowa:THP yaphunziridwa kuti ingathandize kuchepetsa zizindikiro zosiya kugwiritsa ntchito mankhwala osokoneza bongo komanso chizolowezi chogwiritsa ntchito mankhwala osokoneza bongo, zomwe zikupereka chiyembekezo chothandiza pochiza chizolowezi chogwiritsa ntchito mankhwala osokoneza bongo komanso kupewa kubwereranso ku chizolowezicho.
Zinthu izi zikuwonetsa ubwino wosiyanasiyana pa thanzi komanso momwe Tetrahydropalmatine (THP) ingagwiritsidwire ntchito pochiza.
Tetrahydropydalin (dl-THP) ndi ya isoquinoline alkaloids ndipo ndi alkaloid, makamaka ya mtundu wa Corydalis lucidum (Yan Hu Suo), komanso zomera zina monga Stephania rotunda. Zomera izi zimagwiritsidwa ntchito mwachikhalidwe mu mankhwala azitsamba aku China.Corydalis ndi chomera chosatha cha herbaceous, chautali wa masentimita 10 mpaka 20, chokhala ndi mizu yozungulira. Masamba ake pamwamba pa nthaka ndi afupiafupi komanso owonda, okhala ndi mamba pamwamba pa maziko. Masamba oyambira ndi masamba a cauline ali ofanana mu mawonekedwe, okhala ndi mapesi; masamba a cauline amasinthasintha, okhala ndi masamba awiri ndi atatu ophatikizika. Tsamba lachiwiri nthawi zambiri limagawika mopanda bwino ndipo lili ndi mapesi akuya. Masamba ang'onoang'ono ndi ozungulira, ozungulira, kapena ozungulira. Olunjika, pafupifupi 2 cm kutalika, okhala ndi nsonga yopyapyala kapena yakuthwa komanso m'mbali zoyera. Maluwa ake ndi amtundu wa raceme, okhala ndi masamba otsiriza kapena otsutsana; ma bracts ndi otakata lanceolate; maluwa ndi ofiira-ofiirira ndipo amakula mopingasa pa pedicels zoonda, zomwe zimakhala pafupifupi 6 mm kutalika; calyx imagwa msanga; masamba ndi 4 ndipo ma whorls akunja ndi 2. Magawo ndi akulu pang'ono, okhala ndi m'mphepete mwa pinki ndi pakati pa buluu-wofiirira. Pali gawo limodzi lapamwamba, ndipo mchira umafalikira mpaka ku spur yayitali. Kutalika kwa spur kumawerengera pafupifupi theka la kutalika konse. Zigawo ziwiri zamkati ndi zopapatiza kuposa zigawo ziwiri zakunja. Mapeto ake ndi abuluu-wofiirira ndipo amachira, ndipo gawo lapansi ndi pinki; Stamens ndi 6, ndipo ulusiwo umalumikizidwa m'magulu awiri, lililonse lili ndi ma anther atatu; ovary ndi yopyapyala-cylindrical, kalembedwe kake ndi kakafupi komanso kowonda, ndipo stigma ndi ziwiri, ngati gulugufe kakang'ono. Zipatso zake ndi kapisozi. Corydalis imapangidwa makamaka m'mapiri kapena m'malo obiriwira. Madera akuluakulu obereketsa ndi Zhejiang, Hebei, Shandong, Jiangsu, ndi malo ena.
| Kusanthula | Kufotokozera |
| Kuyesa | Tetrahydropalmatine ≥98% |
| Maonekedwe | Ufa wachikasu wopepuka mpaka woyera |
| Phulusa | ≤0.5% |
| Chinyezi | ≤5.0% |
| Mankhwala ophera tizilombo | Zoyipa |
| Zitsulo zolemera | ≤10ppm |
| Pb | ≤2.0ppm |
| As | ≤2.0ppm |
| Fungo | Khalidwe |
| Kukula kwa tinthu | 100% mpaka 80 mauna |
| Zamoyo: | |
| Chiwerengero cha mabakiteriya | ≤1000cfu/g |
| Bowa | ≤100cfu/g |
| Salmgosella | Zoyipa |
| Coli | Zoyipa |
Nayi mafakitale ogwiritsira ntchito zinthu a Tetrahydropalmatine (THP):
1. Mankhwala:THP imagwiritsidwa ntchito mumakampani opanga mankhwala popanga mankhwala ochepetsa ululu ndi mankhwala oteteza mitsempha.
2. Zakudya zopatsa thanzi:THP imagwiritsidwa ntchito mumakampani opanga zakudya zopangira zakudya zowonjezera zomwe zimayang'ana kuchepetsa ululu ndi chithandizo cha thanzi la m'mimba.
3. Ukadaulo wa Zamoyo:THP imapeza ntchito mu biotechnology pofufuza za mankhwala oletsa ma platelet ndi zina zomwe zingatheke pochiza khansa.
4. Chisamaliro chaumoyo:THP imagwiritsidwa ntchito mu mankhwala ochizira matenda amisala pochiza chizolowezi choledzera komanso zizindikiro zosiya kugwiritsa ntchito opioid ndi mankhwala opatsa mphamvu.
5. Zodzoladzola:THP imafufuzidwa mu zodzoladzola kuti ipeze thanzi la khungu komanso ntchito zotsutsana ndi kutupa.
Makampani awa akuwonetsa momwe Tetrahydropalmatine (THP) ingagwiritsidwire ntchito m'njira zosiyanasiyana popanga zinthu ndi kafukufuku.
Zogulitsa zathu zimapangidwa pogwiritsa ntchito njira zowongolera khalidwe ndipo zimatsatira miyezo yapamwamba ya njira zopangira. Timaika patsogolo chitetezo ndi khalidwe la malonda athu, ndikuonetsetsa kuti akukwaniritsa zofunikira za malamulo ndi ziphaso zamakampani. Kudzipereka kumeneku ku khalidwe labwino kumafuna kukhazikitsa chidaliro ndi chidaliro pa kudalirika kwa malonda athu. Njira yonse yopangira ndi iyi:
Malo Osungira:Sungani pamalo ozizira, ouma, komanso oyera, Tetezani ku chinyezi ndi kuwala kolunjika.
Phukusi Lochuluka:20~25kg/ng'oma.
Nthawi yotsogolera:Patatha masiku 7 kuchokera pamene mwaitanitsa.
Moyo wa Shelufu:zaka 2.
Ndemanga:Mafotokozedwe opangidwa mwamakonda akhoza kukwaniritsidwa.
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