Kodi Ubwino wa Ginsenosides ndi Wotani?

Ntchito Yozindikira

Chimodzi mwa zabwino zodziwika bwino za ginsenosides ndi kuthekera kwawo kopititsa patsogolo ntchito ya ubongo. Kafukufuku wambiri wasonyeza kuti ginsenosides imatha kukulitsa kukumbukira, kuphunzira, komanso magwiridwe antchito a ubongo. Zotsatirazi zimaganiziridwa kuti zimachitika kudzera munjira zosiyanasiyana, kuphatikizapo kusintha kwa ma neurotransmitters, monga acetylcholine ndi dopamine, komanso kulimbikitsa neurogenesis, njira yopangira ma neuron atsopano mu ubongo.

Mu kafukufuku wofalitsidwa mu Journal of Ethnopharmacology, ofufuza adapeza kuti ginsenosides ikhoza kusintha kuphunzira kwa malo ndi kukumbukira mwa makoswe mwa kuwonjezera kufotokozedwa kwa neurotrophic factor (BDNF) yochokera mu ubongo, puloteni yomwe imathandizira kupulumuka ndi kukula kwa ma neuron. Kuphatikiza apo, ginsenosides zawonetsedwa kuti zimateteza ku kuchepa kwa chidziwitso chokhudzana ndi ukalamba komanso matenda a neurodegenerative, monga matenda a Alzheimer's ndi Parkinson, mwa kuchepetsa kupsinjika kwa okosijeni ndi kutupa muubongo.

Kusinthasintha kwa Chitetezo cha Mthupi

Mankhwala a ginsenosides apezekanso kuti amasintha chitetezo cha mthupi, ndikuwonjezera mphamvu yake yoteteza ku matenda ndi matenda. Mankhwalawa awonetsedwa kuti amalimbikitsa kupanga ndi kugwira ntchito kwa maselo osiyanasiyana a chitetezo cha mthupi, monga maselo achilengedwe opha, macrophages, ndi ma T lymphocytes, omwe amagwira ntchito yofunika kwambiri poteteza thupi ku matenda ndi maselo a khansa.

Kafukufuku wofalitsidwa mu magazini ya International Immunopharmacology wasonyeza kuti ma ginsenosides amatha kulimbitsa chitetezo cha mthupi mwa mbewa powonjezera kupanga ma cytokines, omwe ndi chizindikiro cha mamolekyu omwe amawongolera magwiridwe antchito a maselo a chitetezo cha mthupi. Kuphatikiza apo, ma ginsenosides awonetsedwa kuti ali ndi mphamvu zotsutsana ndi mavairasi komanso mabakiteriya, zomwe zimapangitsa kuti akhale mankhwala achilengedwe odalirika othandizira thanzi la chitetezo cha mthupi komanso kupewa matenda.

Katundu Wotsutsa Kutupa

Kutupa ndi njira yachilengedwe yotetezera thupi ku kuvulala ndi matenda, koma kutupa kosatha kungathandize pakukula kwa matenda osiyanasiyana, kuphatikizapo matenda a mtima, matenda a shuga, ndi khansa. Mankhwala a ginsenosides apezeka kuti ali ndi mphamvu zotsutsana ndi kutupa, zomwe zingathandize kuchepetsa zotsatirapo zoyipa za kutupa kosatha m'thupi.

Kafukufuku wofalitsidwa mu Journal of Ginseng Research wasonyeza kuti ginsenosides ikhoza kuletsa kupanga ma cytokines oyambitsa kutupa ndikuletsa kuyambika kwa njira zolumikizirana zotupa m'maselo a chitetezo chamthupi. Kuphatikiza apo, ginsenosides zawonetsedwa kuti zimachepetsa kutulutsa kwa zinthu zoyambitsa kutupa, monga cyclooxygenase-2 (COX-2) ndi inducible nitric oxide synthase (iNOS), zomwe zimakhudzidwa ndi kuyankhidwa kwa kutupa.

Ntchito Yoletsa Khansa

Gawo lina lofunika kwambiri pa kafukufuku wa ginsenoside ndi momwe angathandizire polimbana ndi khansa. Kafukufuku wambiri wasonyeza kuti ginsenosides ingakhale ndi zotsatira zotsutsana ndi khansa mwa kuletsa kukula ndi kufalikira kwa maselo a khansa, zomwe zimapangitsa kuti apoptosis (kufa kwa maselo), komanso kuletsa angiogenesis ya chotupa (kupangidwa kwa mitsempha yatsopano yamagazi kuti ithandizire kukula kwa chotupa).

Ndemanga yofalitsidwa mu International Journal of Molecular Sciences inasonyeza mphamvu ya ginsenosides yolimbana ndi khansa, makamaka khansa ya m'mawere, ya m'mapapo, ya chiwindi, ndi ya m'matumbo. Ndemangayi inafotokoza njira zosiyanasiyana zomwe ginsenosides imagwiritsira ntchito polimbana ndi khansa, kuphatikizapo kusintha kwa njira zolumikizirana ndi maselo, kuwongolera kupita patsogolo kwa kayendedwe ka maselo, komanso kuwonjezera chitetezo cha mthupi motsutsana ndi maselo a khansa.

Mapeto

Pomaliza, ginsenosides ndi mankhwala othandiza omwe amapezeka mu Panax ginseng omwe amapereka maubwino osiyanasiyana paumoyo. Izi zikuphatikizapo kusintha kwa magwiridwe antchito a ubongo, kusintha kwa chitetezo chamthupi, mphamvu zotsutsana ndi kutupa, komanso mphamvu zotsutsana ndi khansa. Ngakhale kuti kafukufuku wowonjezereka akufunika kuti timvetsetse bwino momwe ginsenosides imagwirira ntchito komanso mphamvu zochiritsira, umboni womwe ulipo ukusonyeza kuti mankhwala awa ndi othandiza ngati mankhwala achilengedwe olimbikitsa thanzi labwino.

Zolemba
Kim, JH, & Yi, YS (2013). Ginsenoside Rg1 imaletsa kuyambika kwa maselo a dendritic ndi kuchulukana kwa maselo a T mu vitro ndi mu vivo. International Immunopharmacology, 17(3), 355-362.
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Wang, Y., & Liu, J. (2010). Ginseng, njira yodzitetezera ku matenda a mitsempha. Umboni Wochokera ku Umboni ndi Mankhwala Ena, 2012.
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