Mawu Oyamba
Ginsenosidesndi gulu lazinthu zachilengedwe zomwe zimapezeka mumizu ya chomera cha Panax ginseng, chomwe chakhala chikugwiritsidwa ntchito kwazaka zambiri muzamankhwala achi China. Ma bioactive awa atenga chidwi kwambiri m'zaka zaposachedwa chifukwa cha thanzi lawo. M'nkhaniyi, tiwona ubwino wosiyanasiyana wa ginsenosides, kuphatikizapo zotsatira zake pa ntchito yachidziwitso, kusintha kwa chitetezo cha mthupi, anti-inflammatory properties, ndi zomwe zingakhale zotsutsana ndi khansa.
Ntchito Yachidziwitso
Chimodzi mwazabwino zodziwika bwino za ginsenosides ndi kuthekera kwawo kopititsa patsogolo chidziwitso. Kafukufuku wambiri awonetsa kuti ginsenosides imatha kupititsa patsogolo kukumbukira, kuphunzira, komanso kuzindikira kwathunthu. Zotsatirazi zimaganiziridwa kuti zimagwirizanitsidwa kudzera mu njira zosiyanasiyana, kuphatikizapo kusintha kwa ma neurotransmitters, monga acetylcholine ndi dopamine, ndi kulimbikitsa neurogenesis, njira yopangira ma neuron atsopano mu ubongo.
Mu kafukufuku wofalitsidwa mu Journal of Ethnopharmacology , ofufuza adapeza kuti ginsenosides ikhoza kupititsa patsogolo kuphunzira kwa malo ndi kukumbukira makoswe mwa kupititsa patsogolo mawu a ubongo-derived neurotrophic factor (BDNF), puloteni yomwe imathandizira kupulumuka ndi kukula kwa neurons. Kuphatikiza apo, ma ginsenosides awonetsedwa kuti amateteza ku kuchepa kwa chidziwitso chokhudzana ndi ukalamba komanso matenda a neurodegenerative, monga Alzheimer's and Parkinson's disease, pochepetsa kupsinjika kwa okosijeni ndi kutupa mu ubongo.
Kusintha kwa Immune System
Ginsenosides adapezekanso kuti amasintha chitetezo chamthupi, kukulitsa luso lake loteteza ku matenda ndi matenda. Mankhwalawa awonetsedwa kuti amalimbikitsa kupanga ndi kugwira ntchito kwa maselo osiyanasiyana oteteza thupi ku matenda, monga maselo achilengedwe akupha, ma macrophages, ndi ma T lymphocyte, omwe amagwira ntchito yofunika kwambiri poteteza thupi ku tizilombo toyambitsa matenda ndi ma cell a khansa.
Kafukufuku wofalitsidwa mu International Immunopharmacology magazine adawonetsa kuti ginsenosides amatha kupititsa patsogolo chitetezo chamthupi mu mbewa powonjezera kupanga ma cytokines, omwe amawonetsa mamolekyu omwe amawongolera magwiridwe antchito a chitetezo chamthupi. Kuphatikiza apo, ma ginsenosides awonetsedwa kuti ali ndi anti-viral ndi anti-bacterial properties, zomwe zimawapangitsa kukhala chithandizo chachilengedwe chothandizira chitetezo chamthupi komanso kupewa matenda.
Anti-Inflammatory Properties
Kutupa ndi kuyankha kwachilengedwe kwa chitetezo chamthupi kuvulala ndi matenda, koma kutupa kosatha kumathandizira kukulitsa matenda osiyanasiyana, kuphatikiza matenda amtima, shuga, ndi khansa. Ginsenosides apezeka kuti ali ndi mphamvu zotsutsa-kutupa, zomwe zingathandize kuchepetsa zotsatira zoyipa za kutupa kosatha mthupi.
Kafukufuku wofalitsidwa mu Journal of Ginseng Research adawonetsa kuti ginsenosides amatha kupondereza kupanga ma cytokines oyambitsa kutupa ndikuletsa kuyambitsa njira zowonetsera zotupa m'maselo oteteza thupi. Kuonjezera apo, ginsenosides asonyezedwa kuti achepetse kufotokozera kwa oyimira pakati otupa, monga cyclooxygenase-2 (COX-2) ndi inducible nitric oxide synthase (iNOS), zomwe zimakhudzidwa ndi kuyankha kotupa.
Ntchito ya Anticancer
Chinthu chinanso chochititsa chidwi ndi kafukufuku wa ginsenoside ndi ntchito yawo yolimbana ndi khansa. Kafukufuku wambiri wasonyeza kuti ginsenosides atha kukhala ndi zotsatira zotsutsana ndi khansa poletsa kukula ndi kuchuluka kwa maselo a khansa, kupangitsa apoptosis (kufa kwa cell), komanso kupondereza chotupa angiogenesis (kupangidwa kwa mitsempha yatsopano yothandizira kukula kwa chotupa).
Ndemanga yomwe idasindikizidwa mu International Journal of Molecular Sciences idawonetsa kuthekera kwa anticancer kwa ginsenosides, makamaka m'mawere, mapapo, chiwindi, ndi khansa yapakhungu. Ndemangayi idakambirana njira zosiyanasiyana zomwe ma ginsenosides amagwiritsa ntchito zotsutsana ndi khansa, kuphatikiza kusinthika kwa njira zolumikizira ma cell, kuwongolera kayendetsedwe ka ma cell, komanso kupititsa patsogolo chitetezo chamthupi kuma cell a khansa.
Mapeto
Pomaliza, ma ginsenosides ndi mankhwala a bioactive omwe amapezeka mu Panax ginseng omwe amapereka mapindu osiyanasiyana azaumoyo. Izi zikuphatikizapo kusintha kwa chidziwitso, kusinthasintha kwa chitetezo cha mthupi, anti-inflammatory properties, ndi zomwe zingatheke polimbana ndi khansa. Ngakhale kuti kufufuza kwina kuli kofunika kuti mumvetse bwino njira zogwirira ntchito ndi mphamvu zochiritsira za ginsenosides, umboni womwe ulipo umasonyeza kuti mankhwalawa ali ndi lonjezo ngati mankhwala achilengedwe olimbikitsa thanzi labwino ndi thanzi.
Maumboni
Kim, JH, & Yi, YS (2013). Ginsenoside Rg1 imapondereza kuyambitsa kwa ma cell a dendritic ndi kuchuluka kwa T cell mu vitro ndi mu vivo. International Immunopharmacology, 17 (3), 355-362.
Leung, KW, & Wong, AS (2010). Pharmacology ya ginsenosides: kuwunika kwa mabuku. Mankhwala achi China, 5(1), 20.
Radad, K., Gille, G., Liu, L., Rausch, WD, & Kugwiritsa ntchito ginseng muzamankhwala ndikugogomezera matenda a neurodegenerative. Journal of Pharmacological Sciences, 100 (3), 175-186.
Wang, Y., & Liu, J. (2010). Ginseng, njira yodzitetezera ku neuroprotective. Umboni Wothandizira ndi Njira Zina Zamankhwala, 2012.
Yun, TK (2001). Chidule chachidule cha Panax ginseng CA Meyer. Journal ya Korea Medical Science, 16 (Suppl), S3.
Nthawi yotumiza: Apr-16-2024