Kodi Wheat Germ Extract Spermidine ndi chiyani?

Sayansi Pambuyo pa Spermidine

Spermidine ndi polyamine yochitika mwachilengedwe yomwe imagwira ntchito yofunika kwambiri pama cell. Ma polyamines, monga spermidine, ndi ofunikira kuti ma cell akule, achuluke, komanso asamalire bwino. Mankhwalawa amakhudzidwa makamaka ndi kayendetsedwe ka autophagy, njira yomwe thupi limabwezeretsanso ndikuyeretsa maselo owonongeka. Dongosolo lamkati la "kusamalira m'nyumba" ndilofunika kwambiri pa thanzi ndipo tsopano likugwirizanitsidwa ndi kuchepa kwa zaka.

Zotsutsana ndi Kukalamba:Spermidine yakhala ikugwirizana ndi zotsatira zotsutsana ndi ukalamba, chifukwa imapezeka kuti imachepetsedwa ndi ukalamba ndipo imagwirizanitsidwa ndi moyo waufupi komanso zovuta zambiri, kuphatikizapo kusokonezeka kwa chitetezo cha mthupi, matenda otupa, matenda a mtima kapena mitsempha ya mitsempha, ndi tumorigenesis.
Ntchito ya Immune:Spermidine imagwira ntchito yofunika kwambiri pakugwira ntchito kwa maselo a chitetezo chamthupi, kuphatikiza kusiyanitsa ndi kukonza ma T cell, B cell, and natural killer cell (NK). Zimathandizanso polarization ya macrophages kupita ku anti-inflammatory phenotype, motero kumathandiza kuchepetsa kutupa.
Kuyanjana ndi Gut Microbiota:Umboni umasonyeza kuti matumbo a microbiota amatha kupanga spermidine kuchokera ku ma polyamines ena kapena ma precursors awo. Kuyanjana kumeneku pakati pa mabakiteriya ndi wolandirayo kumatha kukhudza kuchuluka kwa spermidine komanso thanzi lonse.
Chitetezo cha mtima:Spermidine yawonetsa zotsatira zamtima, zomwe zingathandize kupewa matenda amtima.
Neuroprotection: Yawonetsanso zotsatira za neuroprotective, zomwe zingakhale zothandiza polimbana ndi matenda a neurodegenerative.
Kupewa Khansa:Polimbikitsa chitetezo chamthupi, spermidine ingathandize kupewa khansa.
Metabolic Regulation: Spermidine imakhudzidwa ndi kagayidwe kachakudya ka polyamines, komwe kumaphatikizapo kuyanjana pakati pa wolandirayo ndi ma microbiota ake.
Mayesero Achipatala ndi Chitetezo:Popeza spermidine imapezeka mwachibadwa m'zakudya za anthu, mayesero achipatala kuti awonjezere kumwa kwake amaonedwa kuti ndi kotheka. Kafukufuku wachitikanso kuti awunike chitetezo cha spermidine, zotsatira za thanzi, kuyamwa, metabolism, ndi bioprocessing.
Pomaliza, spermidine ndi molekyulu yamitundu yambiri yomwe imatha kukhala ndi thanzi lamunthu, kuphatikiza anti-kukalamba, chitetezo chamthupi, komanso chitetezo ku matenda osiyanasiyana. Njira zake zogwirira ntchito zimaphatikizapo kulumikizana ndi matumbo a microbiota, ma cell a chitetezo chamthupi, ndi njira za metabolic. Kafukufuku wowonjezereka ndi mayesero azachipatala atha kufufuza momwe angathere ngati wothandizira.

Mbiri Yazakudya za Tirigu

Tirigu, mbali yoberekera ya njere ya tirigu, imakhala ndi michere yambiri. Lili ndi vitamini E wambiri, magnesium, zinc, ndi fiber. Komabe, chomwe chimapangitsa majeremusi a tirigu kukhala apadera kwambiri ndi ma spermidine ake. Ngakhale kuti ma spermidine ang'onoang'ono amapezeka muzakudya zosiyanasiyana, nyongolosi ya tirigu imapereka mawonekedwe okhazikika, opezeka mosavuta.

Puloteni:Tirigu ndi gwero labwino la mapuloteni, okhala ndi ma amino acid asanu ndi atatu onse, zomwe zimapangitsa kukhala gwero la mapuloteni okwanira.
CHIKWANGWANI:Lili ndi ulusi wosungunuka komanso wosasungunuka, womwe umathandizira chigayidwe komanso umathandizira kuwongolera kuchuluka kwa shuga m'magazi.
Vitamini E:Tirigu ndi chimodzi mwazinthu zolemera kwambiri za vitamini E, makamaka mawonekedwe a tocopherol, omwe ndi antioxidant wamphamvu.
Mavitamini a B:Ndi gwero lambiri la mavitamini a B, kuphatikiza thiamin (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), ndi folate (B9). Mavitaminiwa amagwira ntchito yofunika kwambiri pakupanga mphamvu komanso kupanga maselo ofiira a magazi.
Vitamini B12:Ngakhale sizipezeka muzakudya zamasamba, nyongolosi ya tirigu ndi imodzi mwazomera zochepa za vitamini B12, zomwe ndizofunikira kuti mitsempha igwire ntchito komanso kupanga DNA ndi RNA.
Mafuta acids:Nsomba za tirigu zimakhala ndi mafuta abwino a monounsaturated ndi polyunsaturated, kuphatikizapo omega-3 ndi omega-6 fatty acids, omwe ndi ofunikira pa thanzi la mtima.
Mchere:Ndi gwero la mchere wosiyanasiyana monga magnesium, phosphorous, potaziyamu, zinki, chitsulo, ndi selenium, zomwe ndizofunikira pakugwira ntchito zambiri zathupi.
Phytosterols:Tizilombo toyambitsa matenda timakhala ndi ma phytosterols, omwe ndi mankhwala omwe amathandizira kuchepetsa cholesterol.
Antioxidants:Kupitilira vitamini E, nyongolosi ya tirigu ilinso ndi ma antioxidants ena omwe amathandizira kuteteza maselo ku kuwonongeka koyambitsidwa ndi ma free radicals.
Zakudya zopatsa mphamvu:Amapereka ma carbohydrate ovuta, omwe amagayidwa pang'onopang'ono ndipo amapereka mphamvu zokhazikika.
Tirigu angagwiritsidwe ntchito m'njira zosiyanasiyana, monga zowonjezera mu smoothies, kuwaza pa chimanga, kapena monga chophatikizira muzophika. Chifukwa cha kuchuluka kwake kwamafuta, imatha kukhala yopanda pake ngati siyikusungidwa bwino, chifukwa chake ndikofunikira kuti isungidwe mufiriji kapena kuzizira kuti ikhale yatsopano komanso yopatsa thanzi.

 

Momwe Tirigu Wotulutsa Spermidine Amagwirira Ntchito

Akadyedwa, spermidine kuchokera ku mbewu ya tirigu imatengeka ndikuyamba ntchito yake pama cell. Chimodzi mwazinthu zake zazikulu ndikupititsa patsogolo ntchito ya mitochondrial. Mitochondria, yomwe nthawi zambiri imatchedwa "nyumba zopangira mphamvu" za selo, imapanga mphamvu. Pothandizira ntchito ya mitochondrial, spermidine sikuti imangothandizira kupanga mphamvu komanso imathandizira kuchepetsa kupsinjika kwa okosijeni, chinthu chofunikira kwambiri pakukalamba. Umu ndi momwe zimagwirira ntchito m'thupi:

Autophagy Induction:Imodzi mwa njira zofunika kwambiri zomwe spermidine imaganiziridwa kuti imathandizira kukhala ndi thanzi labwino komanso moyo wautali ndi kusonkhezera kwa autophagy, ndondomeko ya ma cell yomwe imaphatikizapo kuwonongeka ndi kubwezeretsanso zigawo zowonongeka za ma cell. Izi zimagwirizanitsidwa ndi chilolezo cha organelles zowonongeka ndi mapuloteni, omwe amatha kudziunjikira ndi zaka ndikuthandizira matenda osiyanasiyana. Mwa kulimbikitsa autophagy, spermidine ikhoza kuthandizira kukhala ndi thanzi labwino ndi ntchito.

Kuwongolera kwa Gene Expression:Spermidine yasonyezedwa kuti imakhudza chikhalidwe cha acetylation cha histones ndi mapuloteni ena, omwe angakhudze maonekedwe a majini. Zitha kulepheretsa histone acetyltransferases (HATs), zomwe zimatsogolera ku deacetylation ya histones ndikusintha kusindikiza kwa majini omwe amakhudzidwa ndi autophagy ndi njira zina zama cell.

Epigenetic zotsatira:Spermidine imathanso kukhudza epigenome mwa kusintha ma acetylation a histones, omwe ndi mapuloteni omwe DNA imavulala. Izi zitha kukhudza momwe majini amafotokozedwera, motero, magwiridwe antchito am'manja ndi thanzi.

Ntchito ya Mitochondrial:Spermidine yalumikizidwa ndi ntchito yabwino ya mitochondrial, yomwe ndi yofunika kwambiri pakupanga mphamvu m'maselo. Zitha kulimbikitsa kupanga mitochondria yatsopano ndikuwongolera kuchotsedwa kwa zowonongeka kudzera mu njira yotchedwa mitophagy, yomwe ndi mtundu wa autophagy womwe umalimbana makamaka ndi mitochondria.

Zotsutsana ndi kutupa:Spermidine yawonetsa zotsutsana ndi zotupa, zomwe zingakhale zopindulitsa kuchepetsa kutupa komwe kumakhudzana ndi ukalamba ndi matenda osiyanasiyana okhudzana ndi ukalamba.

Chitetezo ku Kupsinjika kwa Oxidative:Monga polyamine, spermidine ikhoza kukhala ngati antioxidant, kuteteza maselo kuti asawonongeke chifukwa cha mitundu yowonjezereka ya okosijeni (ROS), yomwe imakhudzidwa ndi ukalamba ndi matenda ambiri okhudzana ndi ukalamba.

Kukhudzika pa Kuzindikira kwa Nutrient ndi Senescence ya Ma Cellular:Spermidine imathanso kukhala ndi gawo mu njira zowonera michere, zomwe zingakhudze njira zama cell monga kukula, kuchulukana, ndi metabolism. Amaganiziridwa kuti atha kupondereza kukhazikika kwa ma cell, kumangidwa kosasinthika kwa maselo okhudzana ndi ukalamba komanso matenda obwera chifukwa cha ukalamba.

Analimbikitsa Mlingo wa Tirigu Majeremusi Tingafinye Spermidine

Akatswiri amalimbikitsa kuti pakhale spermidine m'zakudya za tsiku ndi tsiku pang'ono, zoyendetsedwa bwino. Mlingo womwe waperekedwa kuti upindule bwino umasiyanasiyana, koma kafukufuku wambiri amalimbikitsa pakati pa 1 mpaka 5 mamiligalamu patsiku. Mlingo wapamwamba, makamaka mu mawonekedwe owonjezera, uyenera kudyedwa mosamala, ndipo m'pofunika kukaonana ndi katswiri wa zachipatala musanayambe njira ina iliyonse yowonjezera yowonjezera.

Kutsiliza: Tsogolo Lowala Lokhala ndi Tirigu Wotulutsa Spermidine

Kutulutsa kwambewu yatirigu spermidine kumapereka mwayi wosangalatsa kwa iwo omwe akufuna kusintha thanzi lawo lonse komanso moyo wautali. Kuthekera kwake kulimbikitsa kusinthika kwa ma cell, kupititsa patsogolo ntchito zamalumikizidwe, ndikuthandizira kukalamba koyenera kumawayika ngati chowonjezera chothandizira. Ndi kafukufuku wopitilira, spermidine posachedwa ikhoza kukhala mwala wapangodya wa thanzi loteteza.