Cycloastragenolndi mankhwala achilengedwe omwe atenga chidwi m'zaka zaposachedwa chifukwa cha mapindu ake azaumoyo. Ndi triterpenoid saponin yomwe imapezeka mumizu ya Astragalus membranaceus, zitsamba zamankhwala zaku China. Gululi lakhala likugwiritsidwa ntchito m'maphunziro ambiri chifukwa cha zomwe akuti anti-kukalamba, anti-inflammatory, ndi immune-modulating properties. M'nkhaniyi, tiwona magwero a cycloastragenol ndi mapindu ake azaumoyo.
Magwero a Cycloastragenol
Astragalus membranaceus: Gwero lalikulu lachilengedwe la cycloastragenol ndiye muzu wa Astragalus membranaceus, yemwe amadziwikanso kuti Huang Qi m'mankhwala achi China. Chitsamba ichi chakhala chikugwiritsidwa ntchito kwazaka zambiri muzamankhwala achi China chifukwa cha zinthu zake zosiyanasiyana zolimbikitsa thanzi. Mizu ya Astragalus membranaceus ili ndi cycloastragenol, pamodzi ndi mankhwala ena a bioactive monga astragaloside IV, polysaccharides, ndi flavonoids.
Zowonjezera: Cycloastragenol imapezekanso mu mawonekedwe owonjezera. Zowonjezera izi nthawi zambiri zimachokera ku muzu wa Astragalus membranaceus ndipo zimagulitsidwa chifukwa cha zomwe zimatha kuletsa kukalamba komanso kulimbikitsa chitetezo chamthupi. Ndikofunikira kudziwa kuti mtundu ndi chiyero cha zowonjezera za cycloastragenol zimatha kusiyana, chifukwa chake ndikofunikira kusankha zinthu kuchokera kwa opanga odziwika.
Ubwino Wathanzi wa Cycloastragenol
Zotsutsana ndi ukalamba: Chimodzi mwazinthu zomwe zimaphunziridwa kwambiri za cycloastragenol ndi zotsatira zake zoletsa kukalamba. Kafukufuku akuwonetsa kuti cycloastragenol imatha kuyambitsa telomerase, puloteni yomwe imagwira ntchito yofunika kwambiri pakusunga utali wa ma telomere, zipewa zoteteza kumapeto kwa ma chromosome. Ma telomere ofupikitsidwa amalumikizidwa ndi ukalamba komanso matenda okhudzana ndi ukalamba, ndipo kuyambitsa kwa telomerase ndi cycloastragenol kungathandize kuteteza kukalamba kwa ma cell.
Zotsutsana ndi zotupa: Cycloastragenol yawonetsedwa kuti ili ndi anti-inflammatory properties, yomwe ingakhale yopindulitsa poyang'anira matenda osiyanasiyana otupa. Kutupa ndi kuyankha kwachilengedwe kwa chitetezo chamthupi, koma kutupa kosatha kumalumikizidwa ndi zovuta zingapo zaumoyo, kuphatikiza matenda amtima, nyamakazi, ndi matenda a neurodegenerative. Pochepetsa kutupa, cycloastragenol ikhoza kuthandizira thanzi labwino komanso thanzi.
Kusinthika kwa Immune: Kafukufuku wasonyeza kuti cycloastragenol imatha kusintha chitetezo chamthupi, kukulitsa luso lake lodziteteza ku matenda ndi matenda. Izi zitha kukhala zopindulitsa makamaka kwa anthu omwe ali ndi vuto la chitetezo chamthupi kapena omwe akufuna kuthandizira chitetezo cha mthupi panthawi yamavuto kapena matenda.
Pomaliza, cycloastragenol ndi chilengedwe chopezeka muzu wa Astragalus membranaceus, ndipo imapezekanso mu mawonekedwe owonjezera. Kafukufuku akuwonetsa kuti cycloastragenol ikhoza kupereka zabwino zomwe zingatheke paumoyo, kuphatikiza anti-kukalamba, anti-yotupa, komanso zolimbitsa thupi. Komabe, maphunziro owonjezera amafunikira kuti amvetsetse bwino momwe amagwirira ntchito komanso zotsatira zake zanthawi yayitali paumoyo wamunthu. Monga chowonjezera china chilichonse, ndikofunikira kukaonana ndi katswiri wazachipatala musanagwiritse ntchito cycloastragenol, makamaka ngati muli ndi vuto lililonse kapena mukumwa mankhwala.
Kodi cycloastragenol ndi yotetezeka?
Chitetezo cha cycloastragenol chakhala nkhani yotsutsana pakati pa ofufuza ndi akatswiri azaumoyo. Ngakhale kuti kafukufuku wina wasonyeza kuti akhoza kukhala ndi thanzi labwino, pali kafukufuku wochepa pa chitetezo chake cha nthawi yaitali komanso zotsatira zake. Zotsatira zake, ndikofunikira kuyandikira kugwiritsa ntchito cycloastragenol mosamala komanso kukaonana ndi katswiri wazachipatala musanayiphatikize pazaumoyo wanu.
Zowopsa zomwe zingatheke ndi zotsatira zake za cycloastragenol
Ngakhale cycloastragenol ikhoza kupereka zopindulitsa paumoyo, palinso nkhawa zokhudzana ndi chitetezo chake komanso zotsatirapo zake. Kafukufuku wochepa wachitika pachitetezo chanthawi yayitali cha cycloastragenol, ndipo chifukwa chake, pali kusowa kwa chidziwitso chokhudza kuopsa kwake komanso zotsatira zake zoyipa.
Anthu ena amatha kukumana ndi zovuta zina akamamwa cycloastragenol, monga kusapeza bwino m'mimba kapena kusamvana. Kuphatikiza apo, chifukwa cycloastragenol yawonetsedwa kuti imasintha chitetezo chamthupi, pali nkhawa kuti itha kukhala ndi mwayi wokulitsa zovuta zina za autoimmune kapena kusokoneza mankhwala opondereza.
Ndikofunikanso kudziwa kuti mtundu ndi chiyero cha zowonjezera za cycloastragenol zimatha kusiyana, ndipo pali chiopsezo choipitsidwa kapena chigololo. Zotsatira zake, ndikofunikira kusankha gwero lodalirika komanso lodalirika pogula zowonjezera za cycloastragenol.
Malingaliro omaliza
Pomaliza, ngakhale cycloastragenol ikuwonetsa lonjezano pazopindulitsa zake zaumoyo, pali kafukufuku wochepera pachitetezo chake chanthawi yayitali komanso zotsatira zake zoyipa. Zotsatira zake, ndikofunikira kuyandikira kugwiritsa ntchito cycloastragenol mosamala komanso kukaonana ndi katswiri wazachipatala musanayiphatikize pazaumoyo wanu. Kuphatikiza apo, ndikofunikira kusankha chowonjezera chapamwamba kuchokera kugwero lodziwika bwino kuti muchepetse chiopsezo choipitsidwa kapena chigololo. Kafukufuku wochulukirapo akufunika kuti amvetsetse bwino zachitetezo ndi mphamvu ya cycloastragenol, ndipo pakadali pano, anthu ayenera kusamala akamaganizira za kugwiritsidwa ntchito kwake.
Zolozera:
1. Lee Y, Kim H, Kim S, et al. Cycloastragenol ndi mphamvu ya telomerase activator m'maselo a neuronal: zomwe zimakhudza kuwongolera kukhumudwa. Neuroreport. 2018;29(3):183-189.
2. Wang Z, Li J, Wang Y, et al. Cycloastragenol, triterpenoid saponin, imathandizira kukula kwa kuyesa kwa autoimmune encephalomyelitis kudzera kuletsa neuroinflammation ndi neurodegeneration. Biochem Pharmacol. 2019; 163:321-335.
3. Liu P, Zhao H, Luo Y. Zotsatira zotsutsa-zotupa za cycloastragenol mu chitsanzo cha mbewa cha LPS-induced mastitis. Kutupa. 2019;42(6):2093-2102.
Nthawi yotumiza: Apr-19-2024